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TobyFish · June 6th, 2007, 05:15 PM

Quote: (Originally Posted by LauNar)

I think they were talking about this study and nitric oxide: http://www.physoc.org/publications/pn/issuepdf/55/16-17.pdf

I recall seeing (Divernet?) news about that, the references to pills being probably a product of the journalistic process, ie. wild imagination and guesswork.

Dr. Alf Brubakk did a nice presentation about that and heat shock proteins etc in the Stockholm Tech Diving 2006 conference.

//LN

Well the Physiological society has certainly lowered it's standards. That would not have been allowed on a poster in my day, let alone a full publication.

they say that exercise prevents bubbles, they say that nitric oxide (NO) prevents bubbles, then they say NO inhibitors don't block the effect of exercise and that this shows that NO is not necessarily the only mechanism of the exercise-effect. HORSE-SHYT!!! this shows that NO is almost certainly UNINVOLVED in the exercise-effect.

You can't take NO as a pill

As far as manipulating NO formation as an anti-bends measure, this is frought with problems. NO is an extremely labile messenger with a biological half-life of less than 10 seconds (from memory about 7) even in well perfused tissues. in poorly perfused tissues or re-perfused tissues, the half-life is likely even shorter. this means that NO normally only acts very close to it's site of production. They are only talking about endothelial NO production which can really only affect the endothelium, underlying vascular smooth muscle and (minimally) cells in the circulation - in short only the local vasculature. Although bubbles are measured in the blood, they are almost certainly formed in the parenchyma as well, and this formation will not be vulnerable to endothelial NO production

Exercise does not simply increase NO production in all endothelium. The effect will be greatest in skeletal muscle and there will likely even be a decrease in tissues such as the intestines. This is part of routing blood to the exercising muscles. so don't count on it being protective of all tissues.

as for "oxide nitrate"...

nitrate IS an oxide. oxide and nitrate are both negative ions, bundling the two together doesn't give you a chemical compound... it just doesn't make sense

June 6th, 2007, 05:15 PM	#4 (permalink)
TobyFish(Offline) Fine Upstanding Member Join Date: May 2006 Location: Telford, UK Posts: 836	Quote: (Originally Posted by LauNar) I think they were talking about this study and nitric oxide: http://www.physoc.org/publications/pn/issuepdf/55/16-17.pdf I recall seeing (Divernet?) news about that, the references to pills being probably a product of the journalistic process, ie. wild imagination and guesswork. Dr. Alf Brubakk did a nice presentation about that and heat shock proteins etc in the Stockholm Tech Diving 2006 conference. //LN Well the Physiological society has certainly lowered it's standards. That would not have been allowed on a poster in my day, let alone a full publication. they say that exercise prevents bubbles, they say that nitric oxide (NO) prevents bubbles, then they say NO inhibitors don't block the effect of exercise and that this shows that NO is not necessarily the only mechanism of the exercise-effect. HORSE-SHYT!!! this shows that NO is almost certainly UNINVOLVED in the exercise-effect. You can't take NO as a pill As far as manipulating NO formation as an anti-bends measure, this is frought with problems. NO is an extremely labile messenger with a biological half-life of less than 10 seconds (from memory about 7) even in well perfused tissues. in poorly perfused tissues or re-perfused tissues, the half-life is likely even shorter. this means that NO normally only acts very close to it's site of production. They are only talking about endothelial NO production which can really only affect the endothelium, underlying vascular smooth muscle and (minimally) cells in the circulation - in short only the local vasculature. Although bubbles are measured in the blood, they are almost certainly formed in the parenchyma as well, and this formation will not be vulnerable to endothelial NO production Exercise does not simply increase NO production in all endothelium. The effect will be greatest in skeletal muscle and there will likely even be a decrease in tissues such as the intestines. This is part of routing blood to the exercising muscles. so don't count on it being protective of all tissues. as for "oxide nitrate"... nitrate IS an oxide. oxide and nitrate are both negative ions, bundling the two together doesn't give you a chemical compound... it just doesn't make sense __________________ Rude-boy Volvo "Gangsta Rollin' in me nine-six-oh"